Author/Authors :
Philip D. Edwards، نويسنده , , Russell C. Mauger، نويسنده , , Kevin M. Cottrell، نويسنده , , Frank X. Morris، نويسنده , , Kara K. Pine، نويسنده , , Mark A. Sylvester، نويسنده , , Clay W. Scott، نويسنده , , Stephen T. Furlong، نويسنده ,
Abstract :
A method for the solid-phase synthesis of P1 arginine containing peptides via attachment of the arginine side-chain guanidine group is described. This procedure is applied to the preparation of a tetrapeptide, P1 arginine aminocoumarin PS-SCL. This library was validated by using it to determine the P4–P2 specificity for thrombin and comparing the results to the known thrombin subsite specificity. This is the first reported example of a PS-SCL library containing a P1 arginine.
