Author/Authors :
Gregory A. Reichard، نويسنده , , Zachary T. Ball، نويسنده , , Robert Aslanian، نويسنده , , John C. Anthes، نويسنده , , Neng-Yang Shih، نويسنده , , John J. Piwinski، نويسنده ,
Abstract :
Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 has resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class. The addition of the amino or the oxime functional group results in the reversal of the stereochemical preference of the NK2 receptor.
