Author/Authors :
Yasunori Aoyama، نويسنده , , Masaaki Uenaka، نويسنده , , Toshiro Konoike*، نويسنده , , Yasuyoshi Iso، نويسنده , , Yasuhiro Nishitani، نويسنده , , Akiko Kanda، نويسنده , , Noriyuki Naya، نويسنده , , Masatoshi Nakajima، نويسنده ,
Abstract :
1-Oxacephem derivatives were evaluated as a novel series of chymase inhibitors. The structure–activity relationship studies of 1-oxacephems led to compounds 15, which exhibited 27 nM inhibition of human chymase and improvement of stability in human plasma (t1/2 1.5 h).
