Title of article :
2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1[]
Author/Authors :
Sepehr Sarshar، نويسنده , , Chengzhi Zhang، نويسنده , , Edmund J. Moran، نويسنده , , Sonja Krane، نويسنده , , Jennifer C. Rodarte، نويسنده , , Khalid D. Benbatoul، نويسنده , , Ross Dixon، نويسنده , , Adnan M. M. Mjalli، نويسنده ,
Abstract :
N-4,5-Di-(4-dialkylamino)phenyl imidazoles (A) are potent modulators of P-glycoprotein mediated multidrug resistance. This manuscript describes the discovery and lead optimization of this novel class of inhibitors.
