Title of article :
Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties
Author/Authors :
Mar?a I. Crespo، نويسنده , , Jordi Gràcia، نويسنده , , Carles Puig، نويسنده , , Armando Vega، نويسنده , , Josep Bou، نويسنده , , Jordi Beleta، نويسنده , , Teresa Doménech، نويسنده , , Hamish Ryder، نويسنده , , Victor Segarra، نويسنده , , Jose M. Palacios، نويسنده ,
Abstract :
A novel series of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones has been prepared. These compounds showed good PDE 4 inhibitory activity and weak affinity for rolipramʹs binding site. They also exhibited a good anti-inflammatory profile without emetic side effects.
