Author/Authors :
Graeme I. Stevenson، نويسنده , , Adrian L. Smith، نويسنده , , Stephen Lewis، نويسنده , , Stephen G. Michie، نويسنده , , Joseph G. Neduvelil، نويسنده , , Smita Patel، نويسنده , , Rosemarie Marwood، نويسنده , , Shil Patel، نويسنده , , José L. Castro، نويسنده ,
Abstract :
A series of 2-aryl tryptamines have been identified as high-affinity h5-HT2A antagonists. Structure–activity relationship studies have shown that h5-HT2A affinity can be attained via modifications to the tryptamine side chain and that selectivity over h5-HT2C and hD2 receptors can be controlled by suitable C-2 aryl groups.
