Title of article
Synthesis and Structure–Activity Relationships of 3-Cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) Inhibitors
Author/Authors
Nan Zhang، نويسنده , , Biqi Wu، نويسنده , , Dennis Powell، نويسنده , , Allan Wissner، نويسنده , , Middleton B. Floyd، نويسنده , , Eleonora D. Kovacs، نويسنده , , Lourdes Toral-Barza، نويسنده , , Constance Kohler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2825
To page
2828
Abstract
A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50ʹs against MAP kinase kinase, and have potent inhibitory activity in tumor cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791214
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