Title of article :
Importance of the C28–C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A
Author/Authors :
Valerie A. Frydrychowski، نويسنده , , Rebecca A. Urbanek، نويسنده , , Amy B. Dounay، نويسنده , , Craig J. Forsyth، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Abstract :
Okadaic acid is a potent inhibitor of select serine/threonine protein phosphatases. The importance of the C28–C38 hydrophobic domain of okadaic acid for inhibition of PP1 and PP2A was investigated. The hydrophobic domain is required but not sufficient for potent inhibition, and it also contributes to differential inhibition between PP1 and PP2A.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
