• Title of article

    Synthesis, modelling and NK1 antagonist evaluation of a non-rigid cyclopropane-containing analogue of CP-99,994

  • Author/Authors

    David J. Aitken، نويسنده , , Sandrine Ongeri، نويسنده , , Danielle Vallée-Goyet، نويسنده , , Jean-Claude Gramain، نويسنده , , Henri-Philippe Husson، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2001
  • Pages
    3
  • From page
    659
  • To page
    661
  • Abstract
    A non-rigid cyclopropane-containing diamine analogue of CP-99,994 was synthesised and was found to have only moderate NK1 receptor binding affinity. Molecular dynamics calculations of the conformational space of the former compound gave good correlation between observed activity and a recently published pharmacophore model, lending predictive value to the latter.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2001
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    791246

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=791246