Title of article
Addressing the stability of C-capped dipeptide efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa
Author/Authors
Thomas E. Renau، نويسنده , , Roger Léger، نويسنده , , Eric M. Flamme، نويسنده , , Miles W. She، نويسنده , , Carla L. Gannon، نويسنده , , Kristina M. Mathias، نويسنده , , Olga Lomovskaya، نويسنده , , Suzanne Chamberland، نويسنده , , Ving J. Lee، نويسنده , , Toshiharu Ohta، نويسنده , , Kiyoshi Nakayama، نويسنده , , Yohei Ishida، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
663
To page
667
Abstract
Synthetic optimization of a biologically labile class of dipeptides that function as efflux pump inhibitors to potentiate the antibacterial agent levofloxacin in Pseudomonas aeruginosa has led to the discovery of a related series of compounds that are completely stable in a variety of biological matrices. Other than the stability profile, the in vitro profile of the new series is essentially identical to that observed with the original one. A prototypical compound from the new series demonstrates potentiation in an in vivo model of infection.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791247
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