Author/Authors :
John G. Darker، نويسنده , , Roderick A. Porter، نويسنده , , Drake S. Eggleston، نويسنده , , Darren Smart، نويسنده , , Stephen J. Brough، نويسنده , , Cibele Sabido-David، نويسنده , , Jeffrey C. Jerman، نويسنده ,
Abstract :
Truncated peptide analogues of orexin-A were prepared and their biological activity assesed at the orexin-1 receptor. Progressive N-terminal deletions identified the minimum C-terminal sequence required for maintaining a significant agonist effect, whilst an alanine scan and other pertinent substitutions identified key side-chain and stereochemical requirements for receptor activation.
