Author/Authors :
Armin Reichenberg، نويسنده , , Jochen Wiesner، نويسنده , , Claus Weidemeyer، نويسنده , , Erhard Dreiseidler، نويسنده , , Silke Sanderbrand، نويسنده , , Boran Altincicek، نويسنده , , Ewald Beck، نويسنده , , Martin Schlitzer، نويسنده , , Hassan Jomaa، نويسنده ,
Abstract :
The fosmidomycin derivative FR900098 represents an inhibitor of the 1-deoxy- -xylulose 5-phosphate (DOXP) reductoisomerase with potent antimalarial activity. Prodrugs of FR900098 with increased activity after oral administration were obtained by chemical modification of the phosphonate moiety to yield phosphodiaryl esters. One diaryl ester prodrug demonstrated efficacy in mice infected with the rodent malaria parasite Plasmodium vinckei comparable to ip drug administration.
