cis- and trans-N-Benzyl-octahydrobenzo[g]quinolines. Adrenergic and Dopaminergic Activity Studies

In vitro assays on a series of cis- and trans-octahydrobenzo[g]quinolines indicated an unusual trend of affinities at the dopaminergic receptors and α adrenoceptors. The transN-benzyl analogues exhibited affinity at the α2 as well as the D1-like receptors whereas their N-unsubstituted congeners showed a distinct preference for the α2 adrenoceptor. Enhanced activity for the α2 receptors was also exhibited by the cisN-benzylated isomers. These observations are interpreted by theoretical calculations.