Author/Authors :
Dieter Starke، نويسنده , , Kerstin Lischka، نويسنده , , Peter Pagels، نويسنده , , Eugen Uhlmann، نويسنده , , Werner Kramer، نويسنده , , Günter Wess، نويسنده , , Ernst Petzinger، نويسنده ,
Abstract :
The synthesis of bile acid–oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid–oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides.
