Title of article
Bile acid–oligodeoxynucleotide conjugates: synthesis and liver excretion in rats
Author/Authors
Dieter Starke، نويسنده , , Kerstin Lischka، نويسنده , , Peter Pagels، نويسنده , , Eugen Uhlmann، نويسنده , , Werner Kramer، نويسنده , , Günter Wess، نويسنده , , Ernst Petzinger، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
945
To page
949
Abstract
The synthesis of bile acid–oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid–oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791312
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