Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists
Author/Authors :
James T. Link، نويسنده , , Bryan Sorensen، نويسنده , , Gang Liu، نويسنده , , Zhonghua Pei، نويسنده , , Edward B. Reilly، نويسنده , , Sandra Leitza، نويسنده , , Greg Okasinski، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
4
From page :
973
To page :
976
Abstract :
Diarylsulfide cyclopropylamides were synthesized and evaluated as LFA-1/ICAM-1 interaction antagonists. A substituent pattern was identified which maximized potency and minimized protein binding as exemplified by antagonist 30 (IC50=5 nM).
