Author/Authors :
Shafinaz F. Chowdhury، نويسنده , , Raffaella Di Lucrezia، نويسنده , , Ramon Hurtado Guerrero، نويسنده , , Reto Brun، نويسنده , , Jonathan Goodman، نويسنده , , Luis M. Ruiz Perez، نويسنده , , Dolores Gonzalez Pacanowska، نويسنده , , Ian H. Gilbert، نويسنده ,
Abstract :
The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzyme and against the intact parasite Leishmania donovani and the related organisms Trypanosoma brucei and Trypanosoma cruzi. The compounds screened showed weak activity in both the enzyme assays and the in vitro assays.
