• Title of article

    Novel inhibitors of leishmanial dihydrofolate reductase

  • Author/Authors

    Shafinaz F. Chowdhury، نويسنده , , Raffaella Di Lucrezia، نويسنده , , Ramon Hurtado Guerrero، نويسنده , , Reto Brun، نويسنده , , Jonathan Goodman، نويسنده , , Luis M. Ruiz Perez، نويسنده , , Dolores Gonzalez Pacanowska، نويسنده , , Ian H. Gilbert، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2001
  • Pages
    4
  • From page
    977
  • To page
    980
  • Abstract
    The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzyme and against the intact parasite Leishmania donovani and the related organisms Trypanosoma brucei and Trypanosoma cruzi. The compounds screened showed weak activity in both the enzyme assays and the in vitro assays.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2001
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    791319

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=791319