Title of article
New oxadiazolidinedione derivatives as potent and selective human β3 agonists
Author/Authors
Baihua Hu، نويسنده , , Michael Malamas، نويسنده , , John Ellingboe، نويسنده , , Elwood Largis، نويسنده , , Stella Han، نويسنده , , Ruth Mulvey، نويسنده , , Jeff Tillett، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
981
To page
984
Abstract
As part of our investigation into the development of potent and selective human β3 agonists, a series of thiazolidinedione analogues was prepared and evaluated for their biological activity on the human β3-adrenergic receptor. The oxadiazolidinedione derivative 17 was found to be the most potent and selective compound in this study, with an EC50 value of 0.02 μM at the β3 receptor, 259-fold selectivity over the β1 receptor, and 745-fold selectivity over the β2 receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791320
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