Title of article
Design, Synthesis and Stability of N-Acyloxymethyl- and N-Aminocarbonyloxymethyl-2-azetidinones as Human Leukocyte Elastase Inhibitors
Author/Authors
A. Clemente، نويسنده , , A. Domingos، نويسنده , , A. P. Grancho، نويسنده , , J. Iley، نويسنده , , Jose R. Moreira، نويسنده , , J. Neres، نويسنده , , N. Palma، نويسنده , , A. B. Santana، نويسنده , , E. Valente، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1065
To page
1068
Abstract
A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the β-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791340
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