Author/Authors :
Antonio Di Stefano، نويسنده , , Barbara Mosciatti، نويسنده , , Gian Mario Cingolani، نويسنده , , Gianfabio Giorgioni، نويسنده , , Massimo Ricciutelli، نويسنده , , Ivana Cacciatore، نويسنده , , Piera Sozio، نويسنده , , Francesco Claudi، نويسنده ,
Abstract :
A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a–d of -Dopa diacetyl esters was synthesized and evaluated as potential -Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of -Dopa in human plasma was observed.
