Title of article
Design and synthesis of a new Sialyl Lewis X Mimetic: How selective are the selectin receptors?
Author/Authors
Marc De Vleeschauwer، نويسنده , , Marc Vaillancourt، نويسنده , , Nathalie Goudreau، نويسنده , , Yvan Guindon، نويسنده , , Denis Gravel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1109
To page
1112
Abstract
The present paper reports the molecular modeling-based design and synthesis of an optically pure noncarbohydrate mimetic of sialyl Lewis X to inhibit E-selectin. Biological evaluation of the designed substance as well as that of its enantiomer gave, contrary to expectations, comparable IC50 values. Results are discussed in terms of receptor binding specificity and the molecular modeling protocol used.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791351
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