Title of article
Conformational analysis of tandospirone in aqueous solution: lead evolution of potent dopamine D4 receptor ligands
Author/Authors
Tamiki Nishimura، نويسنده , , Jun-etsu Igarashi، نويسنده , , Makoto Sunagawa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1141
To page
1144
Abstract
The significant contribution of folded conformation (2) of the anxiolytic tandospirone (1) in aqueous solution was verified by dynamic 1H NMR. A structurally rigid mimic of 2 was designed and synthesized to evaluate the implication of 2 towards neuroleptic receptor binding. The designed structures provided a new rigid scaffold for dopamine D4 ligands.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791358
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