Author/Authors :
Yi Xia، نويسنده , , Zhengyu Yang، نويسنده , , Mann-Jen Hour، نويسنده , , Sheng-Chu Kuo، نويسنده , , Peng-Xia Liu، نويسنده , , Kenneth F. Bastow، نويسنده , , Yuka Nakanishi، نويسنده , , Priya Nampoothiri، نويسنده , , Torben Hackl، نويسنده , , Ernest Hamel، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Abstract :
A series of 2′,3′,4′,6,7-substituted 2-aryl quinazolinones were synthesized and evaluated for biological activity. Among them, 17 displayed significant growth inhibitory action against a panel of tumor cell lines. Compound 17 was also a potent inhibitor of tubulin polymerization. Compounds 8–10 displayed selective activity against P-gp-expressing epidermoid carcinoma of the nasopharynx.
