Author/Authors :
Peter J. Brown، نويسنده , , L. William Stuart، نويسنده , , Kevin P. Hurley، نويسنده , , Michael C. Lewis، نويسنده , , Deborah A. Winegar، نويسنده , , Joan G. Wilson، نويسنده , , William O. Wilkison، نويسنده , , Olivia R. Ittoop، نويسنده , , Timothy M. Willson and Shawn P. Williams، نويسنده ,
Abstract :
Using solid-phase, parallel-array synthesis, a series of urea-substituted thioisobutyric acids was synthesized and assayed for activity on the human PPAR subtypes. GW7647 (3) was identified as a potent human PPARα agonist with 200-fold selectivity over PPARγ and PPARδ, and potent lipid-lowering activity in animal models of dyslipidemia. GW7647 (3) will be a valuable chemical tool for studying the biology of PPARα in human cells and animal models of disease.
