Title of article
Identification of a subtype selective human PPARα agonist through parallel-array synthesis
Author/Authors
Peter J. Brown، نويسنده , , L. William Stuart، نويسنده , , Kevin P. Hurley، نويسنده , , Michael C. Lewis، نويسنده , , Deborah A. Winegar، نويسنده , , Joan G. Wilson، نويسنده , , William O. Wilkison، نويسنده , , Olivia R. Ittoop، نويسنده , , Timothy M. Willson and Shawn P. Williams، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
1225
To page
1227
Abstract
Using solid-phase, parallel-array synthesis, a series of urea-substituted thioisobutyric acids was synthesized and assayed for activity on the human PPAR subtypes. GW7647 (3) was identified as a potent human PPARα agonist with 200-fold selectivity over PPARγ and PPARδ, and potent lipid-lowering activity in animal models of dyslipidemia. GW7647 (3) will be a valuable chemical tool for studying the biology of PPARα in human cells and animal models of disease.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791377
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