Title of article
Influence of the Terminal Amide Fragment Geometry in Some 3-Arylideneindolin-2(1H)-ones on Their 5-HT1A/5-HT2A Receptor Activity[]
Author/Authors
Maria J. Mokrosz، نويسنده , , Sijka Charakchieva-Minol، نويسنده , , Aneta Kozio ، نويسنده , , Aleksandra K odzi ska، نويسنده , , Ewa Chojnacka-W?jcik، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
1229
To page
1231
Abstract
Several 1,4-disubstituted arylpiperazine derivatives of 3-arylideneindolin-2(1H)-one (Z and E isomers) were tested for their 5-HT1A and 5-HT2A receptor activity in vitro and in vivo. It was shown that introduction of 3-arylidene substituents to indolin-2(1H)-one moiety allowed to change the mixed 5-HT1A/5-HT2A receptor ligands to 5-HT2A ones with antagonistic in vivo activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791378
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