Author/Authors :
Kazunao Masubuchi، نويسنده , , Takehiro Okada، نويسنده , , Masami Kohchi، نويسنده , , Takeshi Murata، نويسنده , , Masao Tsukazaki، نويسنده , , Osamu Kondoh، نويسنده , , Toshikazu Yamazaki، نويسنده , , Yasuko Satoh، نويسنده , , Yoshinori Ono، نويسنده , , Toshiyuki Tsukaguchi، نويسنده , , Kazuko Kobayashi، نويسنده , , Naomi Ono، نويسنده , , Tomoaki Inoue، نويسنده , , Ikuo Horii، نويسنده , , Nobuo Shimma، نويسنده ,
Abstract :
Highly potent 1,3-β- -glucan synthase inhibitors, 7b, 10a, 10b and 12, have been identified by the chemical modification of the ornithine residue of a fungicidal macrocyclic lipopeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuteromycotinia spp. These compounds showed stronger antifungal activity against systemic candidiasis as well as pulmonary aspergillosis in mice, and less hepatotoxicity as compared with 1.
