Title of article
Structure–activity relationship investigations of a potent and selective benzodiazepine oxytocin antagonist
Author/Authors
Paul G. Wyatt، نويسنده , , Michael J. Allen، نويسنده , , Josie Chilcott، نويسنده , , Gwen Hickin، نويسنده , , Neil D. Miller، نويسنده , , Patrick M. Woollard، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
1301
To page
1305
Abstract
We have investigated the structure–activity relationships of the 1- and 3-substituents and replacements of the 5-phenyl group of GW405212X 1, a potent selective oxytocin antagonist. The effect of these modifications on oxytocin binding antagonism and on pharmacokinetic parameters is reported.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791396
Link To Document