Author/Authors :
C. Garc?a-Echeverr?a، نويسنده , , P. Imbach، نويسنده , , D. France، نويسنده , , P. Fürst، نويسنده , , M. Lang، نويسنده , , M. Noorani، نويسنده , , Thomas D. Scholz، نويسنده , , J. Zimmermann، نويسنده , , P. Furet، نويسنده ,
Abstract :
We describe the identification and in vitro characterization of a series of 2-aminobenzylstatine derivatives that inhibit non-covalently the chymotrypsin-like activity of the 20S proteasome. Our initial SAR data demonstrate that the 2-aminobenzylstatine core structure can effectively serve as the basis for designing potent, selective and non-covalent inhibitors of the chymotrypsin-like activity of the 20S proteasome
