Author/Authors :
Keith W. Woods، نويسنده , , Richard W. McCroskey، نويسنده , , Michael R. Michaelides، نويسنده , , Carol K. Wada، نويسنده , , Keren I. Hulkower، نويسنده , , Randy L. Bell، نويسنده ,
Abstract :
The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2. Additional substitutions were made at the 1-position and 5-position of the indole of indomethacin.
