Title of article
Design, Synthesis and Enzymatic Activity of Highly Selective Human Mitochondrial Thymidine Kinase Inhibitors
Author/Authors
Stefano Manfredini، نويسنده , , Pier G. Baraldi، نويسنده , , Elisa Durini، نويسنده , , Luca Porcu، نويسنده , , Angela Angusti، نويسنده , , Silvia Vertuani، نويسنده , , Nicola Solaroli، نويسنده , , Erik De Clercq، نويسنده , , Anna Karlsson، نويسنده , , Jan Balzarini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1329
To page
1332
Abstract
Highly selective arabinofuranosyl nucleosides, which inhibit the mitochondrial thymidine kinase (TK-2) without affecting the closely related herpes simplex virus type 1 thymidine kinase (HSV-1 TK), varicella-zoster virus thymidine kinase (VZV-TK), cytosolic thymidine kinase (TK-1) or the multifunctional Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK), have been obtained. SAR studies indicate a close relation between the length of the substituent at the 2′ position of the arabinofuranosyl moiety and the inhibitory activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791402
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