Anodic Oxidation of Ifosfamide and Cyclophosphamide: A Biomimetic Metabolism Model of the Oxazaphosphorinane Anticancer Drugs

The electrochemical oxidation of anticancer drugs ifosfamide and cyclophosphamide produced in high yield methoxylated analogues of the key hydroxy-metabolites of these oxazaphosphorine prodrugs. The cytotoxicity of these compounds was evaluated, and found to be as high as the hydroxy-metabolite.