Title of article :
Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir)
Author/Authors :
Hing L. Sham، نويسنده , , David A. Betebenner، نويسنده , , Thomas Herrin، نويسنده , , Gondi Kumar، نويسنده , , Ayda Saldivar، نويسنده , , Sudthida Vasavanonda، نويسنده , , Akhter Molla، نويسنده , , Dale J. Kempf، نويسنده , , Jacob J. Plattner، نويسنده , , Daniel W. Norbeck، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
3
From page :
1351
To page :
1353
Abstract :
The HIV protease inhibitor ABT-378 (Lopinavir) is metabolized rapidly and extensively by CYP-3A4 catalyzed oxidation. Three of the major metabolites identified were synthesized and their antiviral (HIV) activities determined.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2001
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
791407
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=791407
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