• Title of article

    1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

  • Author/Authors

    Jeffrey J. Hale، نويسنده , , Richard J. Budhu، نويسنده , , Sander G. Mills، نويسنده , , Malcolm MacCoss، نويسنده , , Lorraine Malkowitz، نويسنده , , Salvatore Siciliano، نويسنده , , Sandra L. Gould، نويسنده , , Julie A. DeMartino، نويسنده , , Martin S. Springer، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2001
  • Pages
    4
  • From page
    1437
  • To page
    1440
  • Abstract
    A series of 1,3,4-trisubstituted pyrrolidines was discovered to have the ability to displace [125I]-MIP-1α from the CCR5 receptor expressed on Chinese hamster ovary (CHO) cell membranes. CCR5 activity was found to be dependent on the regiochemistry and the absolute stereochemistry of the pyrrolidine.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2001
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    791427

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=791427