Title of article
Inhibitors of the bacterial cell wall biosynthesis enzyme MurC
Author/Authors
Folkert Reck، نويسنده , , Stephen Marmor، نويسنده , , Stewart Fisher، نويسنده , , Mark A. Wuonola، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1451
To page
1454
Abstract
A series of phosphinate transition-state analogues of the -alanine adding enzyme (MurC) of bacterial peptidoglycan biosynthesis was prepared and tested as inhibitors of the Escherichia coli enzyme. Compound 4 was identified as a potent inhibitor of MurC from Escherichia coli with an IC50 of 49 nM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791430
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