Author/Authors :
Laurent Schio، نويسنده , , Fabienne Chatreaux، نويسنده , , Véronique Loyau، نويسنده , , Michel Murer، نويسنده , , Anne Ferreira، نويسنده , , Pascale Mauvais، نويسنده , , Alain Bonnefoy، نويسنده , , Michel Klich، نويسنده ,
Abstract :
A novel series of novobiocin analogues has been synthesised by removing the lipophilic aryl chain in novobiocin and introducing an amino substituent. The structural modifications have been dictated by the control of lipophilicity and the dissociation constant of the resulting compounds. Antibacterial activity of the new coumarin derivatives could be correlated with the amount of uncharged form in physiological conditions.
