• Title of article

    α-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and α-substitution

  • Author/Authors

    Dale L. Boger، نويسنده , , Hiroshi Miyauchi، نويسنده , , Michael P. Hedrick، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2001
  • Pages
    4
  • From page
    1517
  • To page
    1520
  • Abstract
    Two sets of novel analogues of the recently disclosed α-keto heterocycle inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for regulation of endogenous oleamide and anandamide, were synthesized and evaluated in order to clarify a role of the electrophilic carbonyl group and structural features important for their activity. Both the electrophilic carbonyl and the degree of α-substitution markedly affect inhibitor potency.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2001
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    791444