Title of article
α-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and α-substitution
Author/Authors
Dale L. Boger، نويسنده , , Hiroshi Miyauchi، نويسنده , , Michael P. Hedrick، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1517
To page
1520
Abstract
Two sets of novel analogues of the recently disclosed α-keto heterocycle inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for regulation of endogenous oleamide and anandamide, were synthesized and evaluated in order to clarify a role of the electrophilic carbonyl group and structural features important for their activity. Both the electrophilic carbonyl and the degree of α-substitution markedly affect inhibitor potency.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791444
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