Author/Authors :
Hyoung-Chun Kim، نويسنده , , Toshitaka Nabeshima، نويسنده , , Wang-Kee Jhoo، نويسنده , , Kwang Ho Ko، نويسنده , , Won-Ki Kim، نويسنده , , Eun-Joo Shin، نويسنده , , Minkyoung Cho، نويسنده , , Phil Ho Lee، نويسنده ,
Abstract :
We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.
