Title of article
Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones
Author/Authors
Yasunori Aoyama، نويسنده , , Masaaki Uenaka، نويسنده , , Toshiro Konoike*، نويسنده , , Yoko Hayasaki-Kajiwara، نويسنده , , Noriyuki Naya، نويسنده , , Masatoshi Nakajima، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1691
To page
1694
Abstract
The present work demonstrates that the 1,3-diazetidine-2,4-dione nucleus is effective as a scaffold of serine protease inhibitors. Compound 1 displayed high activity against human cathepsin G and α-chymotrypsin (0.39, 0.69 nM). Compound 6 exhibited 0.85 nM inhibition of human chymase. Compound 10 was a selective inhibitor against human neutrophil elastase.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791482
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