Author/Authors :
Isaac O. Donkor، نويسنده , , Xiaozhang Zheng، نويسنده , , Jie Han
، نويسنده , , Calvin Lacy، نويسنده , , Duane D. Miller، نويسنده ,
Abstract :
α-Ketohydroxamates were synthesized as bioisosteres of α-ketoamides. The α-ketohydroxamates were generally more potent than the corresponding α-ketoamides. The potency of the compounds suggests that hydrogen bonding and steric bulk of substituents on the nitrogen atom of the ketoamide moiety influence calpain inhibition.
