Title of article
Rational design of a new series of pronucleotide
Author/Authors
Thierry Beltran، نويسنده , , David Egron، نويسنده , , Alain Pompon، نويسنده , , Isabelle Lefebvre، نويسنده , , Christian Perigaud، نويسنده , , Gilles Gosselin، نويسنده , , Anne-Marie Aubertin، نويسنده , , Jean-Louis Imbach، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
1775
To page
1777
Abstract
A new pronucleotide series is described involving a two-step degradation process mediated by, respectively, carboxylesterase and phosphoramidase. Taking AZT as nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in TK− cell line, which proves 5′-AZTMP delivery.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791501
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