Author/Authors :
Luisa Savini، نويسنده , , Giuseppe Campiani، نويسنده , , Alessandra Gaeta، نويسنده , , Cesare Pellerano، نويسنده , , Caterina Fattorusso، نويسنده , , Luisa Chiasserini، نويسنده , , James M. Fedorko، نويسنده , , Ashima Saxena، نويسنده ,
Abstract :
Based upon synthetic and biochemical results, a novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed. The role played by the amino groups of homo- and heterobivalent ligands in the interaction with the peripheral and catalytic sites of AChE and BuChE were investigated. The syntheses of these materials together with the results of AChE/BuChE inhibition assays are detailed.
