Author/Authors :
Robert M. Scarborough، نويسنده , , Alan M. Laibelman، نويسنده , , Lane A. Clizbe، نويسنده , , Larry J. Fretto، نويسنده , , Pamela B. Conley، نويسنده , , Elwood E. Reynolds، نويسنده , , David M. Sedlock، نويسنده , , Hans-Michael Jantzen، نويسنده ,
Abstract :
Novel non-nucleoside tricyclic platelet ADP receptor (P2Y12) antagonists have been discovered that bind reversibly and with high affinity to the platelet receptor. Condensation of various 2-aminobenzothiazoles with chlorosulfonylacetyl chloride affords these novel tricyclic heterocycles, which are novel and unpredicted products of this reaction.
