Title of article
Synthesis and biological evaluation of didemnin photoaffinity analogues
Author/Authors
Matthew D. Vera، نويسنده , , Amy J. Pfizenmayer، نويسنده , , Xiaobin Ding، نويسنده , , Deepika Ahuja، نويسنده , , Peter L. Toogood، نويسنده , , Madeleine M. Joullié، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1871
To page
1874
Abstract
The synthesis of four benzophenone-containing analogues of the antiproliferative natural product didemnin B is presented. In vitro protein biosynthesis inhibition potency and antitumor activity were evaluated. The results indicate that all four analogues are biologically active and could serve as photoaffinity reagents for the study of receptor-binding interactions of didemnins. These analogues could also be useful in studying antitumor effects of didemnins.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791522
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