Author/Authors :
Vincent Lisowski، نويسنده , , Cécile Enguehard، نويسنده , , Jean-Charles Lancelot، نويسنده , , Daniel-Henri Caignard، نويسنده , , Stéphanie Lambel، نويسنده , , Stephane Leonce، نويسنده , , Alain Pierre، نويسنده , , Ghanem Atassi، نويسنده , , Pierre Renard، نويسنده , , Sylvain Rault، نويسنده ,
Abstract :
Structure–activity relationship studies of a new series of tripentones (thieno[2,3-b]pyrrolizin-8-ones), led us to prepare several derivatives with antiproliferative activities. The most promising 3-(3-hydroxy-4-methoxyphenyl)thieno[2,3-b]pyrrolizin-8-one 20 (leukemia L1210, IC50=15 nM) was shown to be a potent inhibitor of tubulin polymerization.
