Author/Authors :
Osamu Muraoka، نويسنده , , Manabu Fujimoto، نويسنده , , Genzoh Tanabe، نويسنده , , Michinori Kubo، نويسنده , , Toshie Minematsu، نويسنده , , Hisashi Matsuda، نويسنده , , Toshio Morikawa، نويسنده , , Iwao Toguchida، نويسنده , , Masayuki Yoshikawa، نويسنده ,
Abstract :
Novel 14-norcadinane-type sesquiterpenes, oxyphyllenodiols A and B, and 11,12,13-trinoreudesmane-type sesquiterpenes, oxyphyllenones A and B, were isolated from the methanolic extract of kernels of Alpinia oxyphylla. The absolute stereostructures of these norsesquiterpenes were determined on the basis of physicochemical and chemical evidence. In addition, oxyphyllenodiol A and oxyphyllenone A were found to inhibit the NO production in lipopolysaccharide-activated macrophages.
