Title of article
Synthesis and microtubule binding of fluorescent paclitaxel derivatives
Author/Authors
Erkan Baloglu، نويسنده , , David G. I. Kingston، نويسنده , , Pruthvi Patel، نويسنده , , Sabarni K. Chatterjee، نويسنده , , Susan L. Bane، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2249
To page
2252
Abstract
The preparation of two new fluorescent derivatives of paclitaxel in which the fluorophore is bonded to paclitaxel at the C-10 position is reported. Both analogues, 10-deacetyl-10-(m-aminobenzoyl)paclitaxel (1, BTax) and 10-deacetyl-10-[7-(diethylamino) coumarin-3-carbonyl]paclitaxel (2, CTax) retain good activity as promoters of in vitro tubulin assembly. Microtubule binding enhances the emission intensity of both probes.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791609
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