Title of article
Antimalarial t-butylperoxyamines
Author/Authors
N. Sundar، نويسنده , , V. T. Jacob، نويسنده , , Sujata V. Bhat، نويسنده , , Neena Valecha، نويسنده , , Sukla Biswas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2269
To page
2272
Abstract
Twelve t-butylperoxyamines (6–17) were synthesized as targeted antimalarials and evaluated for antimalarial activity in vivo against Plasmodium berghei in mice and in vitro against both chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum. Compound 8 was found to have highest potency with activity at 80 and 160 mg/kg dose in vivo and compound 11 exhibited highest efficacy in vitro.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791613
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