Author/Authors :
Takayuki Matsuda، نويسنده , , Taro Aoki، نويسنده , , Tadaaki Ohgiya، نويسنده , , Tomoyuki Koshi، نويسنده , , Masao Ohkuchi، نويسنده , , Hiromichi Shigyo، نويسنده ,
Abstract :
New pyridazine derivatives were prepared, and their abilities to inhibit IL-1β production were evaluated. Some compounds showed potent inhibitory activity against IL-1β production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure–activity relationships of these compounds are described.
