Title of article :
Identification of a series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with activity on PPARα, PPARγ, and PPARδ
Author/Authors :
Kevin G. Liu، نويسنده , , Jennifer S. Smith، نويسنده , , Andrea H. Ayscue، نويسنده , , Brad R. Henke، نويسنده , , Millard H. Lambert and H. Eric Xu، نويسنده , , Lisa M. Leesnitzer، نويسنده , , Kelli D. Plunket، نويسنده , , Timothy M. Willson and Shawn P. Williams، نويسنده , , Daniel D. Sternbach، نويسنده ,
Abstract :
A series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with dual agonist activity on PPARα and PPARγ is described. Several of these compounds also showed partial agonist activity on PPARδ. Resolution of one analogue showed that PPARα and PPARγ activity resided in mainly one enantiomer, whereas PPARδ activity was retained in both enantiomers.
