Title of article
Identification of a series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with activity on PPARα, PPARγ, and PPARδ
Author/Authors
Kevin G. Liu، نويسنده , , Jennifer S. Smith، نويسنده , , Andrea H. Ayscue، نويسنده , , Brad R. Henke، نويسنده , , Millard H. Lambert and H. Eric Xu، نويسنده , , Lisa M. Leesnitzer، نويسنده , , Kelli D. Plunket، نويسنده , , Timothy M. Willson and Shawn P. Williams، نويسنده , , Daniel D. Sternbach، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2385
To page
2388
Abstract
A series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with dual agonist activity on PPARα and PPARγ is described. Several of these compounds also showed partial agonist activity on PPARδ. Resolution of one analogue showed that PPARα and PPARγ activity resided in mainly one enantiomer, whereas PPARδ activity was retained in both enantiomers.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791638
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