Synthesis and biological properties of new 1β-methylcarbapenems containing heteroaromatic thioether moiety

The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a–h having heteroaromatic thioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1,2,3-thiadiazole derivative 1h showed the most potent antibacterial activity and advanced pharmacokinetics in comparison with meropenem.