Title of article
Synthesis and biological properties of new 1β-methylcarbapenems containing heteroaromatic thioether moiety
Author/Authors
Kye Jung Shin، نويسنده , , Ki Dong Koo، نويسنده , , Kyung Ho Yoo، نويسنده , , Yong Koo Kang، نويسنده , , Sang Woo Park، نويسنده , , Dong Jin Kim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
2397
To page
2399
Abstract
The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a–h having heteroaromatic thioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1,2,3-thiadiazole derivative 1h showed the most potent antibacterial activity and advanced pharmacokinetics in comparison with meropenem.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791641
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