Author/Authors :
Lisa M. Pratt، نويسنده , , R. Paul Beckett، نويسنده , , Stephen J. Davies، نويسنده , , Steven B. Launchbury، نويسنده , , Tim J Wess and Andrew Miller، نويسنده , , Zoe M. Spavold، نويسنده , , Richard S. Todd، نويسنده , , Mark Whittaker، نويسنده ,
Abstract :
By screening a library of metalloenzyme inhibitors, the N-formyl-hydroxylamine derivative BB-3497 was identified as a potent inhibitor of Escherichia coli peptide deformylase with antibacterial activity both in vitro and in vivo. The homochiral synthesis of BB-3497, involving a novel asymmetric Michael addition reaction is described.
